I agree with everything that Captain Jim says below about cruising the anchorage rich waters of the Ten Thousand Island region. Just know there is also a LOT of shallow water here. We strongly recommend that you have a well functioning GPS chart plotter aboard and operating whenever you cruise the Ten Thousand Islands!
As you’re working your way south (or in the planning stages) you might want to take a closer look at the Everglades. If you like the beauty of unspoiled nature you could spend time anchoring out and or exploring the many Passes that work back into the Everglades and don’t forget the Rod and Gun Club in Everglades City.