It’s a fascinating cruise of some 140 nautical miles from the St. Johns River’s inlet at Mayport, to the city of Sanford on Lake Monroe. And here, cruisers will discover Monroe Harbour Marina, a long-time, cruiser friendly spot!
The safest place I can think of is almost anywhere on the St. Johns river. Monroe Harbour marina is one that I like. It is located in Sanford, which is about 20 miles from Orlando.