Of course, the depths provided by Captain Chuck Baier will change over time, but at least for the rest of March, 2013, and into April, these figures will be of use to anyone contemplating a cruise across the breadth of Florida.
Note that both the Lake and Rim Routes are currently carrying enough depth for the vast majority of cruising craft, but, of course, the Lake Route remains the deeper of the two passages.

Here is the current lake levels. Route 2 is the Rim Route.

U. S. Army Corps of Engineers, Jacksonville District
Lake Okeechobee and Navigation Depth Report
Data Ending 2400 hours 18 MAR 2013
Today’s Lake Okeechobee Stage = 13.94 (Feet-NGVD29)
Today’s Route 1 Navigational Depth ≈ 7.88 Feet
Today’s Route 2 Navigational Depth ≈ 6.08 Feet
Bridge Clearance = 49.71 Feet
Chuck