It looks as if you can avoid the shoal had by marker #17 (see below), many vessels can make it to Everglades City, even at low tide. Of course, to be on the safe side, and that's always a good side to be on, I would much prefer to run this pasage at mid to high water.

Subject: Everglades City Channel
Cruising News: We are a sailboat with a 5 ft. draft and just visited Everglades City. Through a miscalculation we were in the channel at low tide rather than high tide, but made it in except for a shoal near marker 17.The shoal was on the south side and we able to go around it to the north side. On the way out at high tide it was again very shallow at this spot. We also went aground trying to go to Naples on the inside from Marco, but couldn't make it at high tide.
Joan Clark